MOTS-C 10mg

MOTS-C 10mg is a synthetic mitochondrial-derived peptide (MDP) designed for research and laboratory use. MOTS-C is encoded within the mitochondrial 12S rRNA gene and is a 16-amino acid peptide that has been investigated in preclinical models for its role in regulating cellular metabolism, insulin sensitivity, skeletal muscle glucose uptake, and exercise-associated metabolic adaptation. It acts via the AMPK pathway and has been studied as a potential exercise mimetic and metabolic regulator. Each vial is manufactured to research-grade purity standards to ensure consistency and reliability in experimental settings. Ideal for qualified researchers and institutions studying mitochondrial biology, metabolic disease, and bioenergetics. Store at 2–8°C. For research purposes only. Not intended for human or veterinary use.

Specifications: Active Ingredient: MOTS-C (Mitochondrial Open Reading Frame of the 12S rRNA-c) Concentration: 10mg per vial Sequence: Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg (16 amino acids) Molecular Formula: C₁₀₈H₁₇₀N₃₀O₂₈S₂ Molecular Weight: 2,174.5 g/mol Purity: Research grade Form: Lyophilised powder Storage: 2–8°C (refrigerated) Shelf Life: 24 months from manufacture date Reconstitution: Sterile water or saline solution Intended Use: Laboratory and research applications only

Storage Before Reconstitution: Store in original sealed vial at 2–8°C, protected from light and moisture. Stable for 24 months from manufacture date. Avoid repeated freeze-thaw cycles. Storage After Reconstitution: Store reconstituted solution at 2–8°C and use within 7 days. For extended storage, freeze at −20°C or below; thaw at room temperature before use. Avoid multiple freeze-thaw cycles. For research use only. Not intended for human or veterinary use.

Research References

The following peer-reviewed studies and publications are provided for informational and scientific reference purposes only. They do not constitute medical claims or endorsements of this product for any therapeutic use.

1. MOTS-C: Discovery as a Mitochondrial-Derived Peptide
   Lee C, et al. (2015). The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. Cell Metabolism, 21(3), 443–454. https://doi.org/10.1016/j.cmet.2015.02.009
   The foundational discovery paper identifying MOTS-C as a 16-amino acid peptide encoded within the mitochondrial 12S rRNA gene, demonstrating its role in promoting metabolic homeostasis, reducing diet-induced obesity, and improving insulin sensitivity via AMPK activation in mouse models.
2. MOTS-C and Skeletal Muscle Glucose Uptake
   Kim SJ, et al. (2018). MOTS-c: a mitochondrial-derived peptide regulating muscle and fat metabolism. Free Radical Biology and Medicine, 100, 182–187. https://doi.org/10.1016/j.freeradbiomed.2016.05.015
   Reviews MOTS-C’s mechanism of action in skeletal muscle, demonstrating AMPK-dependent glucose transporter (GLUT4) translocation and enhanced glucose uptake — providing key mechanistic context for researchers studying MOTS-C in insulin resistance and metabolic disease models.
3. MOTS-C as an Exercise-Responsive Peptide
   Reynolds JC, et al. (2021). MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis. Nature Communications, 12, 470. https://doi.org/10.1038/s41467-020-20790-0
   Demonstrates that MOTS-C is released from skeletal muscle in response to exercise and acts as a systemic regulator of physical performance and muscle homeostasis in aged mice, establishing its role as an exercise-responsive mitochondrial signal and supporting its research application as an exercise mimetic.
4. MOTS-C and Ageing: Mitochondrial Signalling
   Lu H, et al. (2019). MOTS-c: a promising mitochondrial-derived peptide for therapeutic exploitation. Frontiers in Endocrinology, 10, 1–8. https://doi.org/10.3389/fendo.2019.00632
   Reviews MOTS-C’s role in mitochondrial retrograde signalling, covering its nuclear translocation, regulation of stress-response gene programmes, and potential relevance to age-related metabolic decline — providing a comprehensive mechanistic overview for researchers studying mitochondrial-derived peptides.
5. MOTS-C and Insulin Resistance: AMPK Pathway Activation
   Zhai D, et al. (2017). MOTS-c peptide increases physical endurance and insulin sensitivity in diet-induced obese mice. Frontiers in Physiology, 8, 394. https://doi.org/10.3389/fphys.2017.00394
   Demonstrates that MOTS-C administration increases physical endurance and improves insulin sensitivity in diet-induced obese mouse models via AMPK activation and mitochondrial biogenesis upregulation — providing quantitative metabolic and performance data for exercise mimetic and metabolic disease research protocols.

All references are cited for scientific context only. This product is supplied strictly for in vitro laboratory research. It is not approved for human or veterinary use.