Epithalon 10mg

Epithalon (Epitalon) 10mg is a synthetic tetrapeptide designed for research and laboratory use. Epithalon (Ala-Glu-Asp-Gly) is derived from the endogenous pineal peptide epithalamin and has been investigated in preclinical and clinical research settings for its role in telomerase activation, telomere elongation, circadian rhythm regulation, melatonin synthesis modulation, and age-related biomarker studies. It is one of the most extensively studied peptide bioregulators in the Russian gerontological research literature. Each vial is manufactured to pharmaceutical-grade purity standards to ensure consistency and reliability in research settings. Ideal for qualified researchers and institutions studying peptide bioregulators, pineal biology, and cellular ageing mechanisms. Store at 2–8°C. For research purposes only. Not intended for human or veterinary use.

Specifications: Active Ingredient: Epithalon (Epitalon) — Ala-Glu-Asp-Gly Concentration: 10mg per vial Molecular Formula: C₁₆H₂₇N₅O₈ Molecular Weight: 390.34 g/mol CAS Number: 307297-39-8 Peptide Sequence: Ala-Glu-Asp-Gly (AEDG tetrapeptide) Purity: ≥98% (HPLC) Form: Lyophilised powder Appearance: White to off-white powder pH Range (reconstituted): 4.0–7.0 Endotoxin Level: <5 EU/vial Storage: 2–8°C (refrigerated) Shelf Life: 2 years from manufacture date Reconstitution: Sterile water or saline solution Intended Use: Laboratory and research applications only

Storage Before Reconstitution: Store in original sealed vial at 2–8°C, away from direct sunlight and moisture. Stable for 2 years from manufacture date when stored properly. Storage After Reconstitution: Store reconstituted solution at 2–8°C and use within 24–48 hours for optimal stability. Protect from light. Do not freeze reconstituted solution. Use sterile, pyrogen-free water or saline for reconstitution. Discard if signs of contamination or discolouration appear. For research use only. Not intended for human or veterinary use.

Research References

The following peer-reviewed studies and publications are provided for informational and scientific reference purposes only. They do not constitute medical claims or endorsements of this product for any therapeutic use.

1. Epithalon and Telomerase Activation
   Khavinson VKh, et al. (2003). Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells. Bulletin of Experimental Biology and Medicine, 135(6), 590–592. https://doi.org/10.1023/A:1025493705728
   Demonstrates that epithalon induces telomerase activity and promotes telomere elongation in human somatic cell cultures, establishing its role as a telomerase activator and providing the key mechanistic reference for epithalon research in cellular ageing and replicative senescence models.
2. Epithalon and Pineal Gland Regulation of Melatonin
   Anisimov VN, et al. (2001). Effect of Epitalon on the lifespan increase in Drosophila melanogaster. Mechanisms of Ageing and Development, 122(5), 461–468. https://doi.org/10.1016/S0047-6374(01)00232-X
   Demonstrates significant lifespan extension in Drosophila melanogaster following epithalon administration, providing foundational in vivo data for epithalon’s anti-ageing research profile and establishing its effects on longevity-associated biological pathways.
3. Epithalon and Circadian Rhythm Restoration in Aged Animals
   Khavinson VKh & Morozov VG. (2003). Peptides of pineal gland and thymus prolong human life. Neuroendocrinology Letters, 24(3–4), 233–240. PMID: 14523363
   Reviews the role of pineal-derived peptide bioregulators including epithalon in restoring circadian melatonin secretion rhythms in aged animals and humans, providing research context for epithalon’s application in circadian biology and neuroendocrine ageing studies.
4. Epithalon and Oncostatic Effects in Animal Models
   Anisimov VN, et al. (2003). Inhibitory effect of the peptide epitalon on the development of spontaneous mammary tumors in HER-2/neu transgenic mice. International Journal of Cancer, 101(1), 7–10. https://doi.org/10.1002/ijc.10570
   Demonstrates significant inhibition of spontaneous mammary tumour development in HER-2/neu transgenic mice following epithalon treatment, providing preclinical oncostatic data and expanding the research scope of epithalon into tumour biology and hormonal carcinogenesis models.
5. Epithalon and Biomarkers of Ageing: Long-Term Studies
   Khavinson VKh, et al. (2012). Peptide regulation of ageing. St. Petersburg: Nauka. (See also: Khavinson V & Golubev A. (2002). Bioregulatory peptides and ageing. Annals of the New York Academy of Sciences, 959, 390–398.) https://doi.org/10.1111/j.1749-6632.2002.tb02108.x
   Reviews long-term studies of peptide bioregulators including epithalon on ageing biomarkers in animal and human cohorts, covering effects on immune function, neuroendocrine regulation, and mortality rates — providing the broadest research context for epithalon’s role in gerontological peptide research.

All references are cited for scientific context only. This product is supplied strictly for in vitro laboratory research. It is not approved for human or veterinary use.