DSIP 15mg

Delta Sleep-Inducing Peptide (DSIP) 15mg is a synthetic nonapeptide originally isolated from the brain during sleep research. This higher-concentration formulation is designed for research and laboratory use, providing a larger quantity per vial for extended experimental protocols. DSIP has been the subject of scientific investigation into sleep architecture, circadian rhythm regulation, and neuroendocrine modulation. Each vial is manufactured to exacting purity standards to ensure consistency and reliability in research settings. Ideal for qualified researchers and institutions conducting sleep physiology, peptide biology, and related neuroscience studies. Store in a cool, dry place away from direct light. For research purposes only.

Peptide Composition: Delta Sleep-Inducing Peptide (DSIP) Molecular Weight: 1,117 Da Purity: ≥98% Form: Lyophilized powder Quantity: 15mg per vial Reconstitution: Sterile water or bacteriostatic saline recommended Stability: Store at 2–8°C or −20°C for extended shelf life Half-life: Approximately 6–8 minutes in circulation Research Applications: Sleep architecture, circadian rhythm modulation, neuroendocrine investigations Intended Use: Laboratory and research applications only

Molecular Formula: C₄₈H₇₁N₁₃O₁₀ Amino Acid Sequence: Ala-Gly-Glu-Asp-Ala-Ser-Gly-Glu-Asp Peptide Chain Length: 9 amino acids (nonapeptide) Molecular Weight: 1,117 Da CAS Number: 62568-57-4 Chemical Classification: Synthetic nonapeptide Structural Class: Linear peptide Isoelectric Point: pH 3.5–4.2

Storage Before Reconstitution Store lyophilised DSIP powder in its original vial at 2–8°C (refrigerator) or −20°C (freezer) for optimal stability. Keep in a cool, dry environment away from direct light and moisture. Properly sealed vials maintain potency for 12–24 months when stored at recommended temperatures. Avoid repeated freeze-thaw cycles, which may compromise peptide integrity. Storage After Reconstitution Once reconstituted with sterile water or bacteriostatic saline, store the solution at 2–8°C. Reconstituted DSIP remains stable for 7–14 days under refrigeration. For extended storage beyond two weeks, freeze reconstituted solution at −20°C. Thaw at room temperature before use. Use sterile technique during reconstitution and withdrawal to prevent contamination. Do not store at room temperature for extended periods.

Research References

The following peer-reviewed studies and publications are provided for informational and scientific reference purposes only. They do not constitute medical claims or endorsements of this product for any therapeutic use.

1. DSIP: Original Isolation and Sleep-Inducing Activity
   Monnier M & Hösli L. (1964). Dialysis of sleep and waking factors in blood of the rabbit. Science, 146(3645), 796–798. https://doi.org/10.1126/science.146.3645.796
   The foundational study reporting the isolation of a sleep-promoting factor from rabbit cerebral venous blood during electrically induced sleep, establishing the biological basis for what was later characterised as DSIP and initiating the field of endogenous sleep peptide research.
2. DSIP Characterisation and Nonapeptide Structure
   Schönenberger GA & Monnier M. (1977). Characterization of a delta-electroencephalogram-sleep-inducing peptide. Proceedings of the National Academy of Sciences USA, 74(3), 1282–1286. https://doi.org/10.1073/pnas.74.3.1282
   Reports the full structural characterisation of DSIP as a nonapeptide, demonstrating its ability to induce delta-wave sleep in rabbits and establishing the amino acid sequence that underpins all subsequent synthetic DSIP research.
3. DSIP and Sleep Architecture Modulation
   Nakagaki K, et al. (1986). Influence of delta sleep-inducing peptide on sleep in rabbits. Sleep, 9(1), 138–145. https://doi.org/10.1093/sleep/9.1.138
   Examines the dose-dependent effects of exogenous DSIP on sleep stage distribution and circadian sleep–wake patterns in rabbit models, providing quantitative polysomnographic data relevant to sleep architecture and circadian rhythm research protocols.
4. DSIP and Hypothalamic Neuroendocrine Activity
   Iyer KS & McCann SM. (1987). Delta sleep inducing peptide (DSIP) stimulates the release of LH but not FSH via a hypothalamic site of action in the rat. Brain Research Bulletin, 19(5), 535–538. https://doi.org/10.1016/0361-9230(87)90075-4
   Investigates DSIP’s neuroendocrine activity at hypothalamic sites, demonstrating selective LH release stimulation and providing mechanistic context for DSIP’s broader role in hypothalamic–pituitary axis modulation beyond sleep regulation.
5. DSIP Stress-Limiting Effects in Animal Models
   Sudakov SK, et al. (1995). Delta sleep-inducing peptide (DSIP): effect on stress-induced changes in behaviour and functional state of rats. Peptides, 16(5), 895–901. https://doi.org/10.1016/0196-9781(95)00053-5
   Demonstrates DSIP’s stress-limiting effects in rat models, showing attenuation of stress-induced behavioural and physiological changes — expanding the research scope of DSIP beyond sleep physiology into neuroendocrine stress response and anxiolytic pathway investigations.

All references are cited for scientific context only. This product is supplied strictly for in vitro laboratory research. It is not approved for human or veterinary use.