Semax 5mg

Semax 5mg is a synthetic heptapeptide compound designed for research and laboratory use. This high-purity formulation delivers 5 milligrams of Semax, a synthetic analogue of the adrenocorticotropic hormone (ACTH) 4–7 fragment, suitable for scientific investigation and experimental applications exploring cognitive function, neuroprotection, and neurotrophic factor modulation. Each vial is manufactured to exacting standards to ensure consistency and reliability in research settings. Ideal for qualified researchers and institutions studying peptide interactions with central nervous system pathways, BDNF expression, and neural plasticity. Store in a cool, dry place away from direct light. For research purposes only.

Specifications: Active Ingredient: Semax (synthetic ACTH 4–7 analogue heptapeptide) Concentration: 5mg per vial Purity: Research-grade Format: Lyophilized powder Storage: Cool, dry environment, 2–8°C (refrigerated) Shelf Life: Refer to batch documentation for expiration details Intended Use: Laboratory and research applications only Quality Standard: Manufactured to pharmaceutical-grade consistency protocols Suitable for qualified researchers, academic institutions, and licensed laboratories conducting neuropeptide, cognitive, and neurotrophic research.

Molecular Formula: C₃₈H₅₄N₁₀O₉ Molecular Weight: 751.84 g/mol CAS Number: 80714-61-0 Sequence: Met-Glu-His-Phe-Pro-Gly-Pro Sequence Classification: Synthetic heptapeptide analogue of the ACTH 4–7 fragment (Met-Glu-His-Phe) with a Pro-Gly-Pro C-terminal extension for enhanced metabolic stability and CNS bioavailability Mechanism: Studied for its ability to upregulate BDNF and NGF expression in the brain, modulate dopaminergic and serotonergic neurotransmission, and exert neuroprotective effects under ischaemic and oxidative stress conditions Purity Analysis: ≥98% by HPLC This molecular data supports advanced research into neuropeptide pharmacology, cognitive enhancement mechanisms, and neurotrophic factor regulation studies.

Storage Before Reconstitution: Store the sealed vial at 2–8°C (refrigerated) or at room temperature (15–25°C) in a cool, dry place away from direct sunlight and heat sources. Keep in original packaging to protect from light exposure. Unopened vials maintain stability for the duration specified in batch documentation when stored under these conditions. Storage After Reconstitution: Once reconstituted with bacteriostatic water or sterile saline, store the solution at 2–8°C (refrigerated). Reconstituted solution should be used within the timeframe indicated in your batch documentation. Avoid repeated freeze-thaw cycles, which may compromise peptide integrity. Keep the vial upright and away from direct light during storage. General Handling: Maintain sterile technique during reconstitution. Do not expose to extreme temperatures or prolonged room temperature conditions after mixing. For research use only. Not intended for human or veterinary use.

Research References

The following peer-reviewed studies and publications are provided for informational and scientific reference purposes only. They do not constitute medical claims or endorsements of this product for any therapeutic use.

1. Semax: Design, Synthesis, and Neuroprotective Profile
   Ashmarin IP, et al. (1997). Semax, an analogue of ACTH 4–10 with a broad spectrum of nootropic and neuroprotective properties. Zhurnal Vysshei Nervnoi Deyatelnosti, 47(2), 420–430. PMID: 9181054
   Foundational paper by the original developers of Semax characterising its design as a metabolically stable ACTH 4–7 analogue with a Pro-Gly-Pro C-terminal extension, demonstrating its nootropic and neuroprotective activity in rodent models and establishing the pharmacological basis for all subsequent Semax CNS research.
2. Semax and BDNF Upregulation in the Rat Brain
   Dolotov OV, et al. (2006). Semax, an analogue of ACTH 4–7, regulates expression of BDNF and its receptor TrkB in the basal forebrain of rats. Journal of Neurochemistry, 97(Suppl 1), 82–86. https://doi.org/10.1111/j.1471-4159.2006.03658.x
   Demonstrates that Semax significantly upregulates BDNF mRNA and TrkB receptor expression in the rat basal forebrain, establishing its neurotrophic mechanism of action and providing the key molecular reference for researchers studying Semax in neuroplasticity, learning, and memory consolidation models.
3. Semax and Neuroprotection in Ischaemic Stroke Models
   Gusev EI & Skvortsova VI. (2003). Brain ischemia. Moscow: Medicina. (See also: Gusev EI, et al. (1997). Neuroprotective effects of Semax in patients with cerebral ischaemia. Zhurnal Nevrologii i Psikhiatrii, 97(6), 40–43.) PMID: 9381350
   Clinical and preclinical investigation of Semax's neuroprotective effects in cerebral ischaemia, demonstrating reduced infarct volume, improved neurological outcomes, and attenuation of oxidative stress — providing the translational research basis for Semax in ischaemic neuroprotection and stroke biology models.
4. Semax and Dopaminergic Neurotransmission: Monoamine Modulation
   Levitskaya NG, et al. (2004). Inhibition of the ACTH 4–10 analogue Semax on dopamine catabolism in rat brain. Bulletin of Experimental Biology and Medicine, 138(5), 477–479. https://doi.org/10.1007/s10517-005-0032-z
   Demonstrates that Semax inhibits dopamine catabolism in rat brain regions, modulating monoaminergic neurotransmission and providing mechanistic context for researchers studying Semax's effects on dopaminergic signalling, attention, and motivational neuroscience models.
5. Semax and Gene Expression in the Hippocampus: Transcriptomic Analysis
   Kolomin T, et al. (2013). The new generation of drugs: peptides, their advantages and limitations. International Journal of Peptides, 2013, 386391. (See also: Shadrina MI, et al. (2010). Neuroprotective and neurorestorative effects of Semax peptide in unilateral bulbectomy model in rats. Journal of Molecular Neuroscience, 40(1–2), 185–192.) https://doi.org/10.1007/s12031-009-9248-2
   Transcriptomic and neuroprotective analysis demonstrating Semax-induced regulation of gene networks associated with neurogenesis, synaptic plasticity, and anti-apoptotic signalling in the hippocampus — providing a broad molecular framework for researchers investigating Semax in neural repair, cognitive biology, and neuropeptide gene regulation studies.

All references are cited for scientific context only. This product is supplied strictly for in vitro laboratory research. It is not approved for human or veterinary use.