NAD+ 500mg

NAD+ 500mg is a premium nicotinamide adenine dinucleotide supplement designed to support cellular energy production and metabolic function. Each dose delivers a concentrated 500mg formulation to help optimize NAD+ levels, which naturally decline with age. This science-backed supplement supports mitochondrial health, ATP synthesis, and overall cellular vitality. Ideal for those seeking to maintain energy levels, support cognitive function, and promote longevity at the cellular level. Formulated with precision for maximum bioavailability and efficacy.

Active Ingredient: NAD+ (Nicotinamide Adenine Dinucleotide) 500mg per serving Supports cellular energy metabolism and mitochondrial function. Helps maintain NAD+ levels to promote ATP production, cognitive performance, and cellular longevity. Premium-grade formulation optimized for absorption and efficacy.

Molecular Formula: C₂₁H₂₇N₇O₁₄P₂ NAD+ (Nicotinamide Adenine Dinucleotide) is a coenzyme composed of two nucleotides joined through their phosphate groups. The molecule consists of an adenine nucleotide linked to a nicotinamide nucleotide, forming a critical cofactor in cellular redox reactions and energy metabolism. This structure enables NAD+ to function as an electron carrier in mitochondrial respiration, supporting ATP synthesis and numerous metabolic pathways essential for cellular function and longevity.

Storage Before Reconstitution: Store the sealed container in a cool, dry place between 2–8°C (36–46°F). Protect from light and moisture. Keep away from direct sunlight and heat sources. Maintain in original packaging until use. Shelf life is optimized when stored under these conditions. Storage After Reconstitution: Once reconstituted with sterile water or saline solution, store the prepared solution at 2–8°C (36–46°F) in a sterile, airtight container. Use within 24 hours of reconstitution to maintain stability and potency. Do not freeze. Discard any unused reconstituted solution after the recommended timeframe. Always use sterile technique during preparation to prevent contamination.

Research References

The following peer-reviewed studies and publications are provided for informational and scientific reference purposes only. They do not constitute medical claims or endorsements of this product for any therapeutic use.

1. NAD+ Intermediates: Biology and Therapeutic Potential
   Yoshino J, Baur JA & Imai SI. (2018). NAD+ Intermediates: The Biology and Therapeutic Potential of NMN and NR. Cell Metabolism, 27(3), 513–528. https://doi.org/10.1016/j.cmet.2017.11.002
   Comprehensive review of NAD+ precursor biology, covering the biosynthetic pathways of NMN and NR, their conversion to NAD+, and preclinical evidence for NAD+ repletion in age-related metabolic decline — providing the foundational pharmacological context for NAD+ research in cellular ageing and energy metabolism models.
2. NAD+ in Ageing, Metabolism, and Neurodegeneration
   Verdin E. (2015). NAD+ in aging, metabolism, and neurodegeneration. Science, 350(6265), 1208–1213. https://doi.org/10.1126/science.aac4854
   Landmark review establishing the decline of intracellular NAD+ levels as a hallmark of ageing, demonstrating its consequences for sirtuin and PARP activity, mitochondrial function, and neurodegeneration — providing the key mechanistic rationale for NAD+ repletion research across metabolic and neurodegenerative disease models.
3. NAD+-Boosting Molecules: In Vivo Evidence
   Rajman L, Chwalek K & Sinclair DA. (2018). Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence. Cell Metabolism, 27(3), 529–547. https://doi.org/10.1016/j.cmet.2018.02.011
   Systematic review of in vivo evidence for NAD+ precursor supplementation across multiple animal models, covering improvements in muscle function, energy homeostasis, DNA repair, and lifespan — establishing the translational research basis for NAD+ repletion strategies in ageing and metabolic disease.
4. NAD+ Metabolism and Energy Homeostasis: Mitochondria–Nucleus Axis
   Cantó C, Menzies KJ & Auwerx J. (2015). NAD+ Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus. Cell Metabolism, 22(1), 31–53. https://doi.org/10.1016/j.cmet.2015.05.023
   Detailed mechanistic review of NAD+ as a central regulator of mitochondrial and nuclear energy sensing, covering its role in SIRT1/SIRT3 activation, PARP-1 signalling, and AMPK crosstalk — providing the systems-level metabolic framework for researchers studying NAD+ in mitochondrial biogenesis and cellular stress response.
5. In Vivo NAD+ Assay: Intracellular Levels and Age Dependence in Human Brain
   Zhu XH, Lu M, Lee BY, Ugurbil K & Chen W. (2015). In vivo NAD assay reveals the intracellular NAD contents and redox state in healthy human brain and their age dependences. Proceedings of the National Academy of Sciences, 112(9), 2876–2881. https://doi.org/10.1073/pnas.1417921112
   First in vivo quantification of intracellular NAD+ levels in the healthy human brain using 31P MRS, demonstrating a significant age-dependent decline in cerebral NAD+ and NAD+/NADH redox state — providing direct human translational evidence for NAD+ depletion in brain ageing and establishing a non-invasive measurement framework for NAD+ research.

All references are cited for scientific context only. This product is supplied strictly for in vitro laboratory research. It is not approved for human or veterinary use.