GHK-CU 100mg

GHK-Cu (Glycyl-L-Histidyl-L-Lysine Copper Complex) 100mg is a synthetic tripeptide-copper chelate designed for research and laboratory use. GHK-Cu is a naturally occurring copper-binding tripeptide found in human plasma, saliva, and urine that has been extensively investigated for its roles in collagen and glycosaminoglycan synthesis, wound healing, angiogenesis, anti-inflammatory signalling, and gene expression regulation. This high-concentration 100mg vial is suitable for extended research protocols and multi-experiment programmes. Each vial is manufactured to pharmaceutical-grade purity standards to ensure consistency and reliability in research settings. Ideal for qualified researchers and institutions studying skin biology, tissue repair, and copper-dependent signalling pathways. Store at 2–8°C. For research purposes only. Not intended for human or veterinary use.

Specifications: Active Ingredient: GHK-Cu (Glycyl-L-Histidyl-L-Lysine Copper(II) complex) Concentration: 100mg per vial Molecular Formula: C₁₄H₂₀CuN₆O₅ Molecular Weight: 404.84 g/mol CAS Number: 49557-75-7 IUPAC Name: Copper(II) complex of glycyl-L-histidyl-L-lysine Structural Class: Tripeptide-copper chelate complex Copper Content: ~15.7% by weight (Cu²⁺, square planar coordination) pH Stability Range: 4.0–7.5 Purity: ≥98% (HPLC) Form: Lyophilised powder Appearance: White to off-white crystalline powder Storage: 2–8°C (refrigerated) Shelf Life: 24 months from manufacture date Reconstitution: Sterile water or bacteriostatic saline Intended Use: Laboratory and research applications only

Storage Before Reconstitution: Store in original sealed vial at 2–8°C, away from direct light and moisture. Do not freeze. Stable for 24 months from manufacture date. Storage After Reconstitution: Store reconstituted solution at 2–8°C in a sterile container. Stable for up to 30 days refrigerated; bacteriostatic saline preferred for extended post-reconstitution storage. Avoid repeated freeze-thaw cycles. Use aseptic technique throughout. For research use only. Not intended for human or veterinary use.

Research References

The following peer-reviewed studies and publications are provided for informational and scientific reference purposes only. They do not constitute medical claims or endorsements of this product for any therapeutic use.

1. GHK-Cu: Discovery and Biological Activity
   Pickart L. (1981). The biological effects of the tripeptide glycyl-L-histidyl-L-lysine. Biochemical and Biophysical Research Communications, 100(4), 1585–1591. https://doi.org/10.1016/0006-291X(81)90673-0
   Foundational study by the discoverer of GHK-Cu characterising its biological activity as a naturally occurring copper-binding tripeptide, demonstrating its role in stimulating collagen synthesis and establishing the basis for all subsequent GHK-Cu research in wound healing and tissue repair.
2. GHK-Cu and Collagen Synthesis in Skin Biology
   Pickart L & Margolina A. (2018). Regenerative and protective actions of the GHK-Cu peptide in the light of the new gene data. International Journal of Molecular Sciences, 19(7), 1987. https://doi.org/10.3390/ijms19071987
   Comprehensive review of GHK-Cu’s gene-regulatory activity across 4,000+ human genes, demonstrating upregulation of collagen, elastin, and wound-healing pathways alongside downregulation of inflammatory and oncogenic gene networks — establishing GHK-Cu as a broad-spectrum tissue remodelling research tool.
3. GHK-Cu and Wound Healing: Preclinical Models
   Pickart L, Vasquez-Soltero JM & Margolina A. (2015). GHK peptide as a natural modulator of multiple cellular pathways in skin regeneration. BioMed Research International, 2015, 648108. https://doi.org/10.1155/2015/648108
   Reviews GHK-Cu’s role in stimulating wound contraction, angiogenesis, nerve outgrowth, and anti-inflammatory signalling in preclinical models, providing mechanistic context for skin repair and regenerative biology research applications.
4. GHK-Cu and Anti-Inflammatory Signalling
   Canapp SO Jr, et al. (2003). The effect of topical tripeptide-copper complex on healing of ischemic open wounds. Veterinary Surgery, 32(6), 515–523. https://doi.org/10.1053/j.vetsu.2003.08.003
   Demonstrates GHK-Cu’s promotion of wound closure, granulation tissue formation, and angiogenesis in ischaemic wound models, providing quantitative healing data and establishing its anti-inflammatory and pro-regenerative profile in controlled preclinical research.
5. GHK-Cu and Gene Expression: Antioxidant and Neuroprotective Pathways
   Pickart L, Vasquez-Soltero JM & Margolina A. (2017). The human tripeptide GHK-Cu in prevention of oxidative stress and degenerative conditions of aging: implications for cognitive health. Oxidative Medicine and Cellular Longevity, 2017, 1546138. https://doi.org/10.1155/2017/1546138
   Reviews GHK-Cu’s upregulation of antioxidant defence genes (SOD, catalase, glutathione pathways) and neuroprotective gene networks, providing research context for investigators studying GHK-Cu in oxidative stress, neurodegeneration, and age-related cellular decline models.

All references are cited for scientific context only. This product is supplied strictly for in vitro laboratory research. It is not approved for human or veterinary use.