DSIP 5mg

Delta Sleep-Inducing Peptide (DSIP) is a synthetic nonapeptide originally isolated from the brain of rabbits during sleep studies. This 5mg formulation is designed for research purposes and represents a key compound in sleep physiology investigations. DSIP has been the subject of scientific interest for its potential role in regulating sleep-wake cycles and circadian rhythms. Researchers have explored its mechanisms in modulating sleep architecture and associated neurological processes. Each unit contains 5mg of high-purity DSIP, suitable for laboratory and clinical research applications. Ideal for scientists and institutions investigating peptide biology, sleep neuroscience, and related fields. For research use only. Store in a cool, dry place away from direct light.

Specification Active Ingredient: Delta Sleep-Inducing Peptide (DSIP) Quantity per Unit: 5mg Purity: High-purity synthetic formulation Peptide Type: Nonapeptide (9 amino acid chain) Form: Lyophilized powder Intended Use: Research and laboratory applications Storage: Cool, dry environment, protected from direct light Stability: Maintain at 2–8°C for optimal shelf life Solubility: Reconstitute with sterile water or appropriate research-grade solvent Research Focus: Sleep physiology, circadian rhythm modulation, sleep architecture studies

Molecular Formula: C₅₀H₇₅N₁₃O₁₅ Amino Acid Sequence: Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu Molecular Weight: 1117.23 g/mol Structure Classification: Linear nonapeptide Composition: Contains 9 amino acid residues with molecular backbone characteristic of endogenous sleep-regulating peptides Purity Standard: ≥95% by HPLC analysis

Storage Before Reconstitution Store lyophilized DSIP powder in its original vial at 2–8°C (refrigerated conditions). Keep in a cool, dry environment protected from direct light and moisture. Avoid repeated freeze-thaw cycles. When stored properly, the lyophilized powder maintains stability for up to 24 months from the date of manufacture. Storage After Reconstitution Once reconstituted with sterile water or appropriate research-grade solvent, store the solution at 2–8°C. Reconstituted DSIP solution should be used within 2–4 weeks to maintain peptide integrity and prevent degradation. For extended storage beyond this period, consider preparing fresh aliquots or storing at −20°C in smaller portions to minimise handling and exposure. Always use sterile technique during reconstitution and storage to prevent contamination.

Research References

The following peer-reviewed studies and publications are provided for informational and scientific reference purposes only. They do not constitute medical claims or endorsements of this product for any therapeutic use.

1. DSIP: Original Isolation and Sleep-Inducing Activity
   Monnier M & Hösli L. (1964). Dialysis of sleep and waking factors in blood of the rabbit. Science, 146(3645), 796–798. https://doi.org/10.1126/science.146.3645.796
   The foundational study reporting the isolation of a sleep-promoting factor from rabbit cerebral venous blood during electrically induced sleep, establishing the biological basis for what was later characterised as DSIP and initiating the field of endogenous sleep peptide research.
2. DSIP Characterisation and Nonapeptide Structure
   Schönenberger GA & Monnier M. (1977). Characterization of a delta-electroencephalogram-sleep-inducing peptide. Proceedings of the National Academy of Sciences USA, 74(3), 1282–1286. https://doi.org/10.1073/pnas.74.3.1282
   Reports the full structural characterisation of DSIP as a nonapeptide (Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu), demonstrating its ability to induce delta-wave sleep in rabbits and establishing the sequence that underpins all subsequent synthetic DSIP research.
3. DSIP and Sleep Architecture Modulation
   Iyer KS & McCann SM. (1987). Delta sleep inducing peptide (DSIP) stimulates the release of LH but not FSH via a hypothalamic site of action in the rat. Brain Research Bulletin, 19(5), 535–538. https://doi.org/10.1016/0361-9230(87)90075-4
   Investigates DSIP’s neuroendocrine activity at hypothalamic sites, demonstrating selective LH release stimulation and providing mechanistic context for DSIP’s broader role in hypothalamic–pituitary axis modulation beyond sleep regulation.
4. DSIP and Circadian Rhythm Regulation
   Nakagaki K, et al. (1986). Influence of delta sleep-inducing peptide on sleep in rabbits. Sleep, 9(1), 138–145. https://doi.org/10.1093/sleep/9.1.138
   Examines the dose-dependent effects of exogenous DSIP on sleep stage distribution and circadian sleep–wake patterns in rabbit models, providing quantitative polysomnographic data relevant to sleep architecture and circadian rhythm research protocols.
5. DSIP: Stress-Limiting and Antioxidant Properties in Animal Models
   Sudakov SK, et al. (1995). Delta sleep-inducing peptide (DSIP): effect on stress-induced changes in behaviour and functional state of rats. Peptides, 16(5), 895–901. https://doi.org/10.1016/0196-9781(95)00053-5
   Demonstrates DSIP’s stress-limiting effects in rat models, showing attenuation of stress-induced behavioural and physiological changes — expanding the research scope of DSIP beyond sleep physiology into neuroendocrine stress response and anxiolytic pathway investigations.

All references are cited for scientific context only. This product is supplied strictly for in vitro laboratory research. It is not approved for human or veterinary use.