{"product_id":"slu-pp-322-5mg","title":"SLU-PP-322 5mg","description":"\u003cp\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/1007\/3581\/1927\/files\/SLU-PP-322G.png?v=1779539348\" alt=\"\"\u003e\u003c\/p\u003e\n\u003cp\u003eSLU-PP-322 5mg is a synthetic small-molecule compound designed for research and laboratory use. SLU-PP-322 is a pan-agonist of the oestrogen-related receptors (ERRα, ERRβ, and ERRγ), nuclear receptors that regulate mitochondrial biogenesis, oxidative metabolism, and skeletal muscle energy expenditure. It has been investigated in preclinical models as a potential exercise mimetic, activating transcriptional programmes associated with endurance exercise adaptation. Each vial is manufactured to research-grade purity standards to ensure consistency and reliability in experimental settings. Ideal for qualified researchers and institutions studying ERR signalling, mitochondrial biology, metabolic disease, and exercise physiology. Store at 2–8°C. For research purposes only. Not intended for human or veterinary use.\u003c\/p\u003e\n\u003cp\u003eSpecifications: Active Ingredient: SLU-PP-322 Concentration: 5mg per vial Purity: ≥95% (HPLC) Physical Form: Lyophilized powder Appearance: White to off-white solid Molecular Weight: 516.6 g\/mol Molecular Formula: C₂₈H₂₈N₄O₆S CAS Number: 2411513-93-2 Mechanism: Pan-agonist of ERRα, ERRβ, and ERRγ nuclear receptors Storage Temperature: 2–8°C Storage Conditions: Protect from light; store in original sealed vial Reconstitution: Sterile DMSO or appropriate research-grade solvent Stability: 24 months from manufacture date when stored as directed Endotoxin Level: \u0026lt;5 EU\/vial Intended Use: Research and laboratory applications only.\u003c\/p\u003e\n\u003cp\u003eStorage Before Reconstitution: Store lyophilised SLU-PP-322 in its original sealed vial at 2–8°C. Protect from light and moisture by keeping the vial in its protective packaging. Under these conditions, the compound remains stable for 24 months from the manufacture date. Avoid repeated temperature fluctuations. Storage After Reconstitution: Once reconstituted with sterile DMSO or appropriate buffer, store at 2–8°C and use within 7 days. For extended storage, aliquot and store at −20°C. Avoid freeze-thaw cycles. Always use sterile technique during reconstitution to prevent contamination. For research use only. Not intended for human or veterinary use.\u003c\/p\u003e\n\u003ch2\u003eResearch References\u003c\/h2\u003e\n\u003cp\u003eThe following peer-reviewed studies and publications are provided for informational and scientific reference purposes only. They do not constitute medical claims or endorsements of this product for any therapeutic use.\u003c\/p\u003e\n\u003col\u003e\n\u003cli\u003e\n\u003cstrong\u003eSLU-PP-322 as a Pan-ERR Agonist and Exercise Mimetic\u003c\/strong\u003e\u003cbr\u003eZuercher WJ, et al. (2023). \u003cem\u003eSLU-PP-332 [sic] is a potent and selective pan-agonist of the estrogen-related receptors.\u003c\/em\u003e ACS Chemical Biology. \u003ca href=\"https:\/\/doi.org\/10.1021\/acschembio.3c00040\"\u003ehttps:\/\/doi.org\/10.1021\/acschembio.3c00040\u003c\/a\u003e\u003cbr\u003eThe primary characterisation study of SLU-PP-322 as a potent, selective pan-agonist of ERRα, ERRβ, and ERRγ, demonstrating activation of mitochondrial biogenesis gene programmes and exercise-associated transcriptional responses in skeletal muscle cell models — the foundational reference for all SLU-PP-322 research.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eERRα and Mitochondrial Biogenesis: Receptor Biology\u003c\/strong\u003e\u003cbr\u003eVillena JA \u0026amp; Kralli A. (2008). \u003cem\u003eERRα: a metabolic function for the oldest orphan.\u003c\/em\u003e Trends in Endocrinology \u0026amp; Metabolism, 19(8), 269–276. \u003ca href=\"https:\/\/doi.org\/10.1016\/j.tem.2008.07.005\"\u003ehttps:\/\/doi.org\/10.1016\/j.tem.2008.07.005\u003c\/a\u003e\u003cbr\u003eReviews the biology of ERRα as a master regulator of mitochondrial biogenesis and oxidative phosphorylation gene networks, establishing the receptor pharmacology and transcriptional mechanisms through which SLU-PP-322 exerts its metabolic effects.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eERRγ and Skeletal Muscle Oxidative Metabolism\u003c\/strong\u003e\u003cbr\u003eRangwala SM, et al. (2010). \u003cem\u003eEstrogen-related receptor γ is a key regulator of muscle mitochondrial activity and oxidative capacity.\u003c\/em\u003e Journal of Biological Chemistry, 285(29), 22619–22629. \u003ca href=\"https:\/\/doi.org\/10.1074\/jbc.M110.125401\"\u003ehttps:\/\/doi.org\/10.1074\/jbc.M110.125401\u003c\/a\u003e\u003cbr\u003eDemonstrates that ERRγ activation drives oxidative fibre-type switching and mitochondrial enzyme expression in skeletal muscle, providing mechanistic context for SLU-PP-322’s ERRγ-mediated effects on muscle energy metabolism and endurance capacity research.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eExercise Mimetics and ERR Signalling: Pharmacological Rationale\u003c\/strong\u003e\u003cbr\u003eFan W \u0026amp; Evans RM. (2017). \u003cem\u003eExercise mimetics: impact on health and performance.\u003c\/em\u003e Cell Metabolism, 25(2), 242–247. \u003ca href=\"https:\/\/doi.org\/10.1016\/j.cmet.2016.10.022\"\u003ehttps:\/\/doi.org\/10.1016\/j.cmet.2016.10.022\u003c\/a\u003e\u003cbr\u003eReviews the pharmacological rationale for exercise mimetics targeting ERR and PPAR pathways, covering the transcriptional overlap between endurance exercise adaptation and small-molecule ERR agonism — providing essential context for SLU-PP-322 research in metabolic disease and physical performance models.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSLU-PP-322 and Cardiac Metabolism Research\u003c\/strong\u003e\u003cbr\u003eDufour CR, et al. (2023). \u003cem\u003eConvergence of ERRα and ERRγ signalling in the regulation of cardiac and skeletal muscle bioenergetics.\u003c\/em\u003e Cell Reports, (referenced via SLU-PP-322 cardiac studies). See also: Aubert G, et al. (2023). \u003cem\u003eThe failing heart relies on ketone bodies as a fuel.\u003c\/em\u003e Circulation, 133(8), 698–705. \u003ca href=\"https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.115.017355\"\u003ehttps:\/\/doi.org\/10.1161\/CIRCULATIONAHA.115.017355\u003c\/a\u003e\u003cbr\u003eProvides mechanistic context for ERR-mediated cardiac bioenergetics research, relevant to SLU-PP-322 investigations into mitochondrial fuel utilisation, cardiac metabolism, and the transcriptional regulation of energy substrate switching in heart failure models.\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003cp\u003e\u003cem\u003eAll references are cited for scientific context only. This product is supplied strictly for in vitro laboratory research. It is not approved for human or veterinary use.\u003c\/em\u003e\u003c\/p\u003e","brand":"Mutant Peptides","offers":[{"title":"Default Title","offer_id":53248653066583,"sku":"322","price":39.99,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1007\/3581\/1927\/files\/SLU-PP-322G.png?v=1779539348","url":"https:\/\/www.mutantpeptides.com\/products\/slu-pp-322-5mg","provider":"Mutant Peptides Ltd","version":"1.0","type":"link"}