{"product_id":"semax-5mg","title":"Semax 5mg","description":"\u003cp\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/1007\/3581\/1927\/files\/SEMAX_5MG_GLOSS.png?v=1779037253\" alt=\"\"\u003eSemax 5mg is a synthetic heptapeptide compound designed for research and laboratory use. This high-purity formulation delivers 5 milligrams of Semax, a synthetic analogue of the adrenocorticotropic hormone (ACTH) 4–7 fragment, suitable for scientific investigation and experimental applications exploring cognitive function, neuroprotection, and neurotrophic factor modulation. Each vial is manufactured to exacting standards to ensure consistency and reliability in research settings. Ideal for qualified researchers and institutions studying peptide interactions with central nervous system pathways, BDNF expression, and neural plasticity. Store in a cool, dry place away from direct light. For research purposes only.\u003c\/p\u003e\n\u003cp\u003eSpecifications: Active Ingredient: Semax (synthetic ACTH 4–7 analogue heptapeptide) Concentration: 5mg per vial Purity: Research-grade Format: Lyophilized powder Storage: Cool, dry environment, 2–8°C (refrigerated) Shelf Life: Refer to batch documentation for expiration details Intended Use: Laboratory and research applications only Quality Standard: Manufactured to pharmaceutical-grade consistency protocols Suitable for qualified researchers, academic institutions, and licensed laboratories conducting neuropeptide, cognitive, and neurotrophic research.\u003c\/p\u003e\n\u003cp\u003eMolecular Formula: C₃₈H₅₄N₁₀O₉ Molecular Weight: 751.84 g\/mol CAS Number: 80714-61-0 Sequence: Met-Glu-His-Phe-Pro-Gly-Pro Sequence Classification: Synthetic heptapeptide analogue of the ACTH 4–7 fragment (Met-Glu-His-Phe) with a Pro-Gly-Pro C-terminal extension for enhanced metabolic stability and CNS bioavailability Mechanism: Studied for its ability to upregulate BDNF and NGF expression in the brain, modulate dopaminergic and serotonergic neurotransmission, and exert neuroprotective effects under ischaemic and oxidative stress conditions Purity Analysis: ≥98% by HPLC This molecular data supports advanced research into neuropeptide pharmacology, cognitive enhancement mechanisms, and neurotrophic factor regulation studies.\u003c\/p\u003e\n\u003cp\u003eStorage Before Reconstitution: Store the sealed vial at 2–8°C (refrigerated) or at room temperature (15–25°C) in a cool, dry place away from direct sunlight and heat sources. Keep in original packaging to protect from light exposure. Unopened vials maintain stability for the duration specified in batch documentation when stored under these conditions. Storage After Reconstitution: Once reconstituted with bacteriostatic water or sterile saline, store the solution at 2–8°C (refrigerated). Reconstituted solution should be used within the timeframe indicated in your batch documentation. Avoid repeated freeze-thaw cycles, which may compromise peptide integrity. Keep the vial upright and away from direct light during storage. General Handling: Maintain sterile technique during reconstitution. Do not expose to extreme temperatures or prolonged room temperature conditions after mixing. For research use only. Not intended for human or veterinary use.\u003c\/p\u003e\n\u003ch2\u003eResearch References\u003c\/h2\u003e\n\u003cp\u003eThe following peer-reviewed studies and publications are provided for informational and scientific reference purposes only. They do not constitute medical claims or endorsements of this product for any therapeutic use.\u003c\/p\u003e\n\u003col\u003e\n\u003cli\u003e\n\u003cstrong\u003eSemax: Design, Synthesis, and Neuroprotective Profile\u003c\/strong\u003e\u003cbr\u003eAshmarin IP, et al. (1997). \u003cem\u003eSemax, an analogue of ACTH 4–10 with a broad spectrum of nootropic and neuroprotective properties.\u003c\/em\u003e Zhurnal Vysshei Nervnoi Deyatelnosti, 47(2), 420–430. PMID: 9181054\u003cbr\u003eFoundational paper by the original developers of Semax characterising its design as a metabolically stable ACTH 4–7 analogue with a Pro-Gly-Pro C-terminal extension, demonstrating its nootropic and neuroprotective activity in rodent models and establishing the pharmacological basis for all subsequent Semax CNS research.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSemax and BDNF Upregulation in the Rat Brain\u003c\/strong\u003e\u003cbr\u003eDolotov OV, et al. (2006). \u003cem\u003eSemax, an analogue of ACTH 4–7, regulates expression of BDNF and its receptor TrkB in the basal forebrain of rats.\u003c\/em\u003e Journal of Neurochemistry, 97(Suppl 1), 82–86. \u003ca href=\"https:\/\/doi.org\/10.1111\/j.1471-4159.2006.03658.x\"\u003ehttps:\/\/doi.org\/10.1111\/j.1471-4159.2006.03658.x\u003c\/a\u003e\u003cbr\u003eDemonstrates that Semax significantly upregulates BDNF mRNA and TrkB receptor expression in the rat basal forebrain, establishing its neurotrophic mechanism of action and providing the key molecular reference for researchers studying Semax in neuroplasticity, learning, and memory consolidation models.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSemax and Neuroprotection in Ischaemic Stroke Models\u003c\/strong\u003e\u003cbr\u003eGusev EI \u0026amp; Skvortsova VI. (2003). \u003cem\u003eBrain ischemia.\u003c\/em\u003e Moscow: Medicina. (See also: Gusev EI, et al. (1997). \u003cem\u003eNeuroprotective effects of Semax in patients with cerebral ischaemia.\u003c\/em\u003e Zhurnal Nevrologii i Psikhiatrii, 97(6), 40–43.) PMID: 9381350\u003cbr\u003eClinical and preclinical investigation of Semax's neuroprotective effects in cerebral ischaemia, demonstrating reduced infarct volume, improved neurological outcomes, and attenuation of oxidative stress — providing the translational research basis for Semax in ischaemic neuroprotection and stroke biology models.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSemax and Dopaminergic Neurotransmission: Monoamine Modulation\u003c\/strong\u003e\u003cbr\u003eLevitskaya NG, et al. (2004). \u003cem\u003eInhibition of the ACTH 4–10 analogue Semax on dopamine catabolism in rat brain.\u003c\/em\u003e Bulletin of Experimental Biology and Medicine, 138(5), 477–479. \u003ca href=\"https:\/\/doi.org\/10.1007\/s10517-005-0032-z\"\u003ehttps:\/\/doi.org\/10.1007\/s10517-005-0032-z\u003c\/a\u003e\u003cbr\u003eDemonstrates that Semax inhibits dopamine catabolism in rat brain regions, modulating monoaminergic neurotransmission and providing mechanistic context for researchers studying Semax's effects on dopaminergic signalling, attention, and motivational neuroscience models.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSemax and Gene Expression in the Hippocampus: Transcriptomic Analysis\u003c\/strong\u003e\u003cbr\u003eKolomin T, et al. (2013). \u003cem\u003eThe new generation of drugs: peptides, their advantages and limitations.\u003c\/em\u003e International Journal of Peptides, 2013, 386391. (See also: Shadrina MI, et al. (2010). \u003cem\u003eNeuroprotective and neurorestorative effects of Semax peptide in unilateral bulbectomy model in rats.\u003c\/em\u003e Journal of Molecular Neuroscience, 40(1–2), 185–192.) \u003ca href=\"https:\/\/doi.org\/10.1007\/s12031-009-9248-2\"\u003ehttps:\/\/doi.org\/10.1007\/s12031-009-9248-2\u003c\/a\u003e\u003cbr\u003eTranscriptomic and neuroprotective analysis demonstrating Semax-induced regulation of gene networks associated with neurogenesis, synaptic plasticity, and anti-apoptotic signalling in the hippocampus — providing a broad molecular framework for researchers investigating Semax in neural repair, cognitive biology, and neuropeptide gene regulation studies.\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003cp\u003e\u003cem\u003eAll references are cited for scientific context only. This product is supplied strictly for in vitro laboratory research. It is not approved for human or veterinary use.\u003c\/em\u003e\u003c\/p\u003e","brand":"Mutant Peptides","offers":[{"title":"Default Title","offer_id":53248662307159,"sku":"XA5","price":14.99,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1007\/3581\/1927\/files\/SEMAX_5MG_GLOSS.png?v=1779037254","url":"https:\/\/www.mutantpeptides.com\/products\/semax-5mg","provider":"Mutant Peptides Ltd","version":"1.0","type":"link"}