{"product_id":"mots-c-10mg","title":"MOTS-C 10mg","description":"\u003cp\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/1007\/3581\/1927\/files\/mots-c-10mg_d9774d34-db34-4f0e-befc-8f1e992cc126.png?v=1779544171\" alt=\"\"\u003e\u003c\/p\u003e\n\u003cp\u003eMOTS-C 10mg is a synthetic mitochondrial-derived peptide (MDP) designed for research and laboratory use. MOTS-C is encoded within the mitochondrial 12S rRNA gene and is a 16-amino acid peptide that has been investigated in preclinical models for its role in regulating cellular metabolism, insulin sensitivity, skeletal muscle glucose uptake, and exercise-associated metabolic adaptation. It acts via the AMPK pathway and has been studied as a potential exercise mimetic and metabolic regulator. Each vial is manufactured to research-grade purity standards to ensure consistency and reliability in experimental settings. Ideal for qualified researchers and institutions studying mitochondrial biology, metabolic disease, and bioenergetics. Store at 2–8°C. For research purposes only. Not intended for human or veterinary use.\u003c\/p\u003e\n\u003cp\u003eSpecifications: Active Ingredient: MOTS-C (Mitochondrial Open Reading Frame of the 12S rRNA-c) Concentration: 10mg per vial Sequence: Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg (16 amino acids) Molecular Formula: C₁₀₈H₁₇₀N₃₀O₂₈S₂ Molecular Weight: 2,174.5 g\/mol Purity: Research grade Form: Lyophilised powder Storage: 2–8°C (refrigerated) Shelf Life: 24 months from manufacture date Reconstitution: Sterile water or saline solution Intended Use: Laboratory and research applications only\u003c\/p\u003e\n\u003cp\u003eStorage Before Reconstitution: Store in original sealed vial at 2–8°C, protected from light and moisture. Stable for 24 months from manufacture date. Avoid repeated freeze-thaw cycles. Storage After Reconstitution: Store reconstituted solution at 2–8°C and use within 7 days. For extended storage, freeze at −20°C or below; thaw at room temperature before use. Avoid multiple freeze-thaw cycles. For research use only. Not intended for human or veterinary use.\u003c\/p\u003e\n\u003ch2\u003eResearch References\u003c\/h2\u003e\n\u003cp\u003eThe following peer-reviewed studies and publications are provided for informational and scientific reference purposes only. They do not constitute medical claims or endorsements of this product for any therapeutic use.\u003c\/p\u003e\n\u003col\u003e\n\u003cli\u003e\n\u003cstrong\u003eMOTS-C: Discovery as a Mitochondrial-Derived Peptide\u003c\/strong\u003e\u003cbr\u003eLee C, et al. (2015). \u003cem\u003eThe mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance.\u003c\/em\u003e Cell Metabolism, 21(3), 443–454. \u003ca href=\"https:\/\/doi.org\/10.1016\/j.cmet.2015.02.009\"\u003ehttps:\/\/doi.org\/10.1016\/j.cmet.2015.02.009\u003c\/a\u003e\u003cbr\u003eThe foundational discovery paper identifying MOTS-C as a 16-amino acid peptide encoded within the mitochondrial 12S rRNA gene, demonstrating its role in promoting metabolic homeostasis, reducing diet-induced obesity, and improving insulin sensitivity via AMPK activation in mouse models.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMOTS-C and Skeletal Muscle Glucose Uptake\u003c\/strong\u003e\u003cbr\u003eKim SJ, et al. (2018). \u003cem\u003eMOTS-c: a mitochondrial-derived peptide regulating muscle and fat metabolism.\u003c\/em\u003e Free Radical Biology and Medicine, 100, 182–187. \u003ca href=\"https:\/\/doi.org\/10.1016\/j.freeradbiomed.2016.05.015\"\u003ehttps:\/\/doi.org\/10.1016\/j.freeradbiomed.2016.05.015\u003c\/a\u003e\u003cbr\u003eReviews MOTS-C’s mechanism of action in skeletal muscle, demonstrating AMPK-dependent glucose transporter (GLUT4) translocation and enhanced glucose uptake — providing key mechanistic context for researchers studying MOTS-C in insulin resistance and metabolic disease models.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMOTS-C as an Exercise-Responsive Peptide\u003c\/strong\u003e\u003cbr\u003eReynolds JC, et al. (2021). \u003cem\u003eMOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis.\u003c\/em\u003e Nature Communications, 12, 470. \u003ca href=\"https:\/\/doi.org\/10.1038\/s41467-020-20790-0\"\u003ehttps:\/\/doi.org\/10.1038\/s41467-020-20790-0\u003c\/a\u003e\u003cbr\u003eDemonstrates that MOTS-C is released from skeletal muscle in response to exercise and acts as a systemic regulator of physical performance and muscle homeostasis in aged mice, establishing its role as an exercise-responsive mitochondrial signal and supporting its research application as an exercise mimetic.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMOTS-C and Ageing: Mitochondrial Signalling\u003c\/strong\u003e\u003cbr\u003eLu H, et al. (2019). \u003cem\u003eMOTS-c: a promising mitochondrial-derived peptide for therapeutic exploitation.\u003c\/em\u003e Frontiers in Endocrinology, 10, 1–8. \u003ca href=\"https:\/\/doi.org\/10.3389\/fendo.2019.00632\"\u003ehttps:\/\/doi.org\/10.3389\/fendo.2019.00632\u003c\/a\u003e\u003cbr\u003eReviews MOTS-C’s role in mitochondrial retrograde signalling, covering its nuclear translocation, regulation of stress-response gene programmes, and potential relevance to age-related metabolic decline — providing a comprehensive mechanistic overview for researchers studying mitochondrial-derived peptides.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMOTS-C and Insulin Resistance: AMPK Pathway Activation\u003c\/strong\u003e\u003cbr\u003eZhai D, et al. (2017). \u003cem\u003eMOTS-c peptide increases physical endurance and insulin sensitivity in diet-induced obese mice.\u003c\/em\u003e Frontiers in Physiology, 8, 394. \u003ca href=\"https:\/\/doi.org\/10.3389\/fphys.2017.00394\"\u003ehttps:\/\/doi.org\/10.3389\/fphys.2017.00394\u003c\/a\u003e\u003cbr\u003eDemonstrates that MOTS-C administration increases physical endurance and improves insulin sensitivity in diet-induced obese mouse models via AMPK activation and mitochondrial biogenesis upregulation — providing quantitative metabolic and performance data for exercise mimetic and metabolic disease research protocols.\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003cp\u003e\u003cem\u003eAll references are cited for scientific context only. This product is supplied strictly for in vitro laboratory research. It is not approved for human or veterinary use.\u003c\/em\u003e\u003c\/p\u003e","brand":"Mutant Peptides","offers":[{"title":"Default Title","offer_id":53248638124375,"sku":"MS10","price":23.99,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1007\/3581\/1927\/files\/mots-c-10mg_d9774d34-db34-4f0e-befc-8f1e992cc126.png?v=1779544171","url":"https:\/\/www.mutantpeptides.com\/products\/mots-c-10mg","provider":"Mutant Peptides Ltd","version":"1.0","type":"link"}