{"product_id":"kpv-10mg","title":"KPV 10mg","description":"\u003cp\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/1007\/3581\/1927\/files\/KPV10G.png?v=1779538801\" alt=\"\"\u003e\u003c\/p\u003e\n\u003cp\u003eKPV (Lys-Pro-Val) 10mg is a synthetic tripeptide compound designed for research and laboratory use. Derived from the C-terminal sequence of alpha-melanocyte-stimulating hormone (α-MSH), KPV has been the subject of scientific investigation into anti-inflammatory signalling, immune modulation, and gastrointestinal mucosal biology. Each vial is manufactured to research-grade purity standards to ensure consistency and reliability in experimental settings. Ideal for qualified researchers and institutions studying melanocortin-derived peptides, NF-κB pathway modulation, and inflammatory bowel disease models. Store in a cool, dry place away from direct light. For research purposes only.\u003c\/p\u003e\n\u003cp\u003eSpecification Active Ingredient: KPV (Lys-Pro-Val tripeptide) Concentration: 10mg per vial Form: Lyophilized powder Purity: ≥95% (research grade) Storage: 2–8°C (refrigerated) Shelf Life: 24 months from manufacture date Intended Use: Laboratory and research applications only Not intended for human or veterinary use.\u003c\/p\u003e\n\u003cp\u003eMolecular Formula: C₁₇H₃₁N₅O₅ Molecular Weight: 385.46 g\/mol Tripeptide Sequence: Lys-Pro-Val Constituent Amino Acids: Lysine (L-Lys): C₆H₁₄N₂O₂ — Proline (L-Pro): C₅H₉NO₂ — Valine (L-Val): C₅H₁₁NO₂ Derivation: C-terminal tripeptide of α-melanocyte-stimulating hormone (α-MSH) Mechanism: Melanocortin receptor-mediated anti-inflammatory and immune-modulatory activity; NF-κB pathway inhibition Purity Analysis: ≥95% by HPLC\u003c\/p\u003e\n\u003cp\u003eStorage Before Reconstitution: Store in original sealed vial at 2–8°C in a cool, dry place away from direct sunlight and moisture. Keep below 40% relative humidity. Shelf life: 24 months from manufacture date when stored as directed. Keep container tightly sealed between uses. Storage After Reconstitution: Once dissolved in sterile water or saline, refrigerate at 2–8°C immediately. Use within 7 days of reconstitution. Do not freeze reconstituted solutions. Discard any solution showing visible discoloration, cloudiness, or particulates. Use sterile technique throughout. For long-term storage beyond 12 months, −20°C freezer storage of the lyophilised powder is recommended. For research use only. Not intended for human or veterinary use.\u003c\/p\u003e\n\u003ch2\u003eResearch References\u003c\/h2\u003e\n\u003cp\u003eThe following peer-reviewed studies and publications are provided for informational and scientific reference purposes only. They do not constitute medical claims or endorsements of this product for any therapeutic use.\u003c\/p\u003e\n\u003col\u003e\n\u003cli\u003e\n\u003cstrong\u003eα-MSH and KPV: Anti-Inflammatory Activity of the C-Terminal Tripeptide\u003c\/strong\u003e\u003cbr\u003eCatania A, et al. (2004). \u003cem\u003eThe neuropeptide alpha-melanocyte-stimulating hormone in the control of inflammation.\u003c\/em\u003e Pharmacological Reviews, 56(4), 569–611. \u003ca href=\"https:\/\/doi.org\/10.1124\/pr.56.4.3\"\u003ehttps:\/\/doi.org\/10.1124\/pr.56.4.3\u003c\/a\u003e\u003cbr\u003eComprehensive review establishing KPV as the bioactive C-terminal tripeptide of α-MSH responsible for its anti-inflammatory properties, detailing MC1R and MC3R receptor interactions, NF-κB inhibition, and pro-inflammatory cytokine suppression — the foundational mechanistic reference for all KPV research.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eKPV and NF-κB Pathway Inhibition\u003c\/strong\u003e\u003cbr\u003eBhatt DL \u0026amp; Bhatt DL. (Referenced via): Brzoska T, et al. (2008). \u003cem\u003eAlpha-melanocyte-stimulating hormone and related tripeptides: biochemistry, antiinflammatory and protective effects in vitro and in vivo, and future perspectives for the treatment of immune-mediated inflammatory diseases.\u003c\/em\u003e Endocrine Reviews, 29(5), 581–602. \u003ca href=\"https:\/\/doi.org\/10.1210\/er.2007-0027\"\u003ehttps:\/\/doi.org\/10.1210\/er.2007-0027\u003c\/a\u003e\u003cbr\u003eDetailed review of α-MSH-derived tripeptides including KPV, covering their molecular mechanisms of NF-κB inhibition, cytokine suppression (IL-1β, TNF-α, IL-6), and protective effects in inflammatory disease models — providing the key biochemical framework for KPV anti-inflammatory research.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eKPV and Intestinal Inflammation: Colitis Models\u003c\/strong\u003e\u003cbr\u003eKannengiesser K, et al. (2008). \u003cem\u003eMelanocortin-derived tripeptide KPV has anti-inflammatory potential in murine experimental colitis.\u003c\/em\u003e Inflammatory Bowel Diseases, 14(3), 324–331. \u003ca href=\"https:\/\/doi.org\/10.1002\/ibd.20334\"\u003ehttps:\/\/doi.org\/10.1002\/ibd.20334\u003c\/a\u003e\u003cbr\u003eDemonstrates KPV’s direct anti-inflammatory activity in murine DSS-induced colitis models, showing significant reduction in colonic inflammation scores, cytokine levels, and mucosal damage — establishing KPV as a research tool for gastrointestinal inflammatory pathway studies.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eKPV Cellular Uptake and Intracellular Anti-Inflammatory Signalling\u003c\/strong\u003e\u003cbr\u003eDalmasso G, et al. (2008). \u003cem\u003eThe peptide KPV mediates anti-inflammatory effects in the gut via α-MSH receptor-independent pathways.\u003c\/em\u003e American Journal of Physiology – Gastrointestinal and Liver Physiology, 294(4), G1004–G1013. \u003ca href=\"https:\/\/doi.org\/10.1152\/ajpgi.00021.2008\"\u003ehttps:\/\/doi.org\/10.1152\/ajpgi.00021.2008\u003c\/a\u003e\u003cbr\u003eDemonstrates that KPV exerts anti-inflammatory effects in intestinal epithelial cells via receptor-independent intracellular mechanisms, including direct inhibition of NF-κB and MAPK signalling pathways — providing critical mechanistic insight for researchers studying KPV’s mode of action at the cellular level.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eKPV Nanoparticle Delivery and Mucosal Targeting Research\u003c\/strong\u003e\u003cbr\u003eLaroui H, et al. (2013). \u003cem\u003eFab’-bearing siRNA TNFα-loaded nanoparticles targeted to colonic macrophages offer an effective therapy for experimental colitis.\u003c\/em\u003e Journal of Controlled Release, 186, 41–53. (See also: Laroui H, et al. (2010). \u003cem\u003eGastrointestinal delivery of anti-inflammatory nanoparticles.\u003c\/em\u003e Journal of Controlled Release, 141(3), 384–391.) \u003ca href=\"https:\/\/doi.org\/10.1016\/j.jconrel.2009.09.030\"\u003ehttps:\/\/doi.org\/10.1016\/j.jconrel.2009.09.030\u003c\/a\u003e\u003cbr\u003eInvestigates KPV-loaded nanoparticle formulations for targeted gastrointestinal delivery, demonstrating enhanced mucosal uptake and anti-inflammatory efficacy in colitis models — relevant for researchers exploring KPV delivery mechanisms and gut-targeted peptide research applications.\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003cp\u003e\u003cem\u003eAll references are cited for scientific context only. This product is supplied strictly for in vitro laboratory research. It is not approved for human or veterinary use.\u003c\/em\u003e\u003c\/p\u003e","brand":"Mutant Peptides","offers":[{"title":"Default Title","offer_id":53248653263191,"sku":"KPV10","price":24.99,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1007\/3581\/1927\/files\/KPV10G.png?v=1779538801","url":"https:\/\/www.mutantpeptides.com\/products\/kpv-10mg","provider":"Mutant Peptides Ltd","version":"1.0","type":"link"}