{"product_id":"epithalon-10mg","title":"Epithalon 10mg","description":"\u003cp\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/1007\/3581\/1927\/files\/epithalon-10mg_e783f39e-d77c-4338-91ff-99e79e5c3155.png?v=1779543799\" alt=\"\"\u003e\u003c\/p\u003e\n\u003cp\u003eEpithalon (Epitalon) 10mg is a synthetic tetrapeptide designed for research and laboratory use. Epithalon (Ala-Glu-Asp-Gly) is derived from the endogenous pineal peptide epithalamin and has been investigated in preclinical and clinical research settings for its role in telomerase activation, telomere elongation, circadian rhythm regulation, melatonin synthesis modulation, and age-related biomarker studies. It is one of the most extensively studied peptide bioregulators in the Russian gerontological research literature. Each vial is manufactured to pharmaceutical-grade purity standards to ensure consistency and reliability in research settings. Ideal for qualified researchers and institutions studying peptide bioregulators, pineal biology, and cellular ageing mechanisms. Store at 2–8°C. For research purposes only. Not intended for human or veterinary use.\u003c\/p\u003e\n\u003cp\u003eSpecifications: Active Ingredient: Epithalon (Epitalon) — Ala-Glu-Asp-Gly Concentration: 10mg per vial Molecular Formula: C₁₆H₂₇N₅O₈ Molecular Weight: 390.34 g\/mol CAS Number: 307297-39-8 Peptide Sequence: Ala-Glu-Asp-Gly (AEDG tetrapeptide) Purity: ≥98% (HPLC) Form: Lyophilised powder Appearance: White to off-white powder pH Range (reconstituted): 4.0–7.0 Endotoxin Level: \u0026lt;5 EU\/vial Storage: 2–8°C (refrigerated) Shelf Life: 2 years from manufacture date Reconstitution: Sterile water or saline solution Intended Use: Laboratory and research applications only\u003c\/p\u003e\n\u003cp\u003eStorage Before Reconstitution: Store in original sealed vial at 2–8°C, away from direct sunlight and moisture. Stable for 2 years from manufacture date when stored properly. Storage After Reconstitution: Store reconstituted solution at 2–8°C and use within 24–48 hours for optimal stability. Protect from light. Do not freeze reconstituted solution. Use sterile, pyrogen-free water or saline for reconstitution. Discard if signs of contamination or discolouration appear. For research use only. Not intended for human or veterinary use.\u003c\/p\u003e\n\u003ch2\u003eResearch References\u003c\/h2\u003e\n\u003cp\u003eThe following peer-reviewed studies and publications are provided for informational and scientific reference purposes only. They do not constitute medical claims or endorsements of this product for any therapeutic use.\u003c\/p\u003e\n\u003col\u003e\n\u003cli\u003e\n\u003cstrong\u003eEpithalon and Telomerase Activation\u003c\/strong\u003e\u003cbr\u003eKhavinson VKh, et al. (2003). \u003cem\u003eEpithalon peptide induces telomerase activity and telomere elongation in human somatic cells.\u003c\/em\u003e Bulletin of Experimental Biology and Medicine, 135(6), 590–592. \u003ca href=\"https:\/\/doi.org\/10.1023\/A:1025493705728\"\u003ehttps:\/\/doi.org\/10.1023\/A:1025493705728\u003c\/a\u003e\u003cbr\u003eDemonstrates that epithalon induces telomerase activity and promotes telomere elongation in human somatic cell cultures, establishing its role as a telomerase activator and providing the key mechanistic reference for epithalon research in cellular ageing and replicative senescence models.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eEpithalon and Pineal Gland Regulation of Melatonin\u003c\/strong\u003e\u003cbr\u003eAnisimov VN, et al. (2001). \u003cem\u003eEffect of Epitalon on the lifespan increase in Drosophila melanogaster.\u003c\/em\u003e Mechanisms of Ageing and Development, 122(5), 461–468. \u003ca href=\"https:\/\/doi.org\/10.1016\/S0047-6374(01)00232-X\"\u003ehttps:\/\/doi.org\/10.1016\/S0047-6374(01)00232-X\u003c\/a\u003e\u003cbr\u003eDemonstrates significant lifespan extension in Drosophila melanogaster following epithalon administration, providing foundational in vivo data for epithalon’s anti-ageing research profile and establishing its effects on longevity-associated biological pathways.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eEpithalon and Circadian Rhythm Restoration in Aged Animals\u003c\/strong\u003e\u003cbr\u003eKhavinson VKh \u0026amp; Morozov VG. (2003). \u003cem\u003ePeptides of pineal gland and thymus prolong human life.\u003c\/em\u003e Neuroendocrinology Letters, 24(3–4), 233–240. PMID: 14523363\u003cbr\u003eReviews the role of pineal-derived peptide bioregulators including epithalon in restoring circadian melatonin secretion rhythms in aged animals and humans, providing research context for epithalon’s application in circadian biology and neuroendocrine ageing studies.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eEpithalon and Oncostatic Effects in Animal Models\u003c\/strong\u003e\u003cbr\u003eAnisimov VN, et al. (2003). \u003cem\u003eInhibitory effect of the peptide epitalon on the development of spontaneous mammary tumors in HER-2\/neu transgenic mice.\u003c\/em\u003e International Journal of Cancer, 101(1), 7–10. \u003ca href=\"https:\/\/doi.org\/10.1002\/ijc.10570\"\u003ehttps:\/\/doi.org\/10.1002\/ijc.10570\u003c\/a\u003e\u003cbr\u003eDemonstrates significant inhibition of spontaneous mammary tumour development in HER-2\/neu transgenic mice following epithalon treatment, providing preclinical oncostatic data and expanding the research scope of epithalon into tumour biology and hormonal carcinogenesis models.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eEpithalon and Biomarkers of Ageing: Long-Term Studies\u003c\/strong\u003e\u003cbr\u003eKhavinson VKh, et al. (2012). \u003cem\u003ePeptide regulation of ageing.\u003c\/em\u003e St. Petersburg: Nauka. (See also: Khavinson V \u0026amp; Golubev A. (2002). \u003cem\u003eBioregulatory peptides and ageing.\u003c\/em\u003e Annals of the New York Academy of Sciences, 959, 390–398.) \u003ca href=\"https:\/\/doi.org\/10.1111\/j.1749-6632.2002.tb02108.x\"\u003ehttps:\/\/doi.org\/10.1111\/j.1749-6632.2002.tb02108.x\u003c\/a\u003e\u003cbr\u003eReviews long-term studies of peptide bioregulators including epithalon on ageing biomarkers in animal and human cohorts, covering effects on immune function, neuroendocrine regulation, and mortality rates — providing the broadest research context for epithalon’s role in gerontological peptide research.\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003cp\u003e\u003cem\u003eAll references are cited for scientific context only. This product is supplied strictly for in vitro laboratory research. It is not approved for human or veterinary use.\u003c\/em\u003e\u003c\/p\u003e","brand":"Mutant Peptides","offers":[{"title":"Default Title","offer_id":53248638910807,"sku":"ET10","price":16.99,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1007\/3581\/1927\/files\/epithalon-10mg_e783f39e-d77c-4338-91ff-99e79e5c3155.png?v=1779543799","url":"https:\/\/www.mutantpeptides.com\/products\/epithalon-10mg","provider":"Mutant Peptides Ltd","version":"1.0","type":"link"}